Press Releases
 
HKBU develops world-first metal-based probes for detection of dopamine receptors, a cancer biomarker

Discovery can be potentially developed as a novel early cancer detection technology.

HONG KONG, 16 May 2018 -- (ACN Newswire) -- A team led by Dr Edmond Ma Dik-lung, Associate Professor of the Department of Chemistry of Hong Kong Baptist University (HKBU) has developed the world's first iridium(III)-based probes for imaging dopamine receptors in living cells. The discovery has enhanced the understanding of dopamine receptors in carcinogenesis, and the findings can be potentially developed as a novel early cancer detection technology. The study was published in the inside front cover of Chemical Science, the flagship journal of the Royal Society of Chemistry.

Dopamine is an important neurotransmitter in the central nervous system of the human body and plays important roles in motivation, cognition and motor control. While dopamine receptors have long been implicated in neurodegenerative diseases, such as Parkinson's disease, recent evidence has linked dopamine receptors also with various cancers, including lung, breast and colon cancers. Traditional detection methods for dopamine receptors include the enzyme-linked immunosorbent assay (ELISA). However, such methods suffer from high cost, incompatibility with living systems, and are not suitable for the real-time study of the biological role of dopamine receptors.

The metal-based probes developed by the team are able to selectively bind to dopamine receptors on lung cancer cells, "lighting up" the cells and making them visible to the naked eye. The probes enable the monitoring and tracking of dopamine receptors in living cells in a real-time and in a non-invasive fashion. Moreover, the experiment results demonstrated that the imaging colour intensity was correlates with the expression levels of dopamine receptors on cancer cells. These probes could therefore both help to elucidate the role of dopamine receptors in the pathogenesis of cancers and offer a potential diagnostic tool for the early screening of cancers. Importantly, the metal-based probes avoid the problems of poor photostability and photobleaching that limit conventional fluorescent imaging dyes.

The research project entitled "Cell imaging of dopamine receptor using agonist labeling iridium(III) complex" was led by Dr Edmond Ma of HKBU together with Professor Leung Chung-hang of the Institute of Chinese Medical Sciences, University of Macau. Other collaborators of the project included researchers from the School of Chinese Medicine of HKBU, the City University of Hong Kong, University of Florida, USA, and Hunan University, China.

Dr Ma said, "Early detection is crucial for improving the survival rate of hard-to-treat cancers such as lung cancer, which is associated with dopamine receptor expression. For instance, data from the American Cancer Society shows that patients with early stage non-small cell lung cancer (NSCLC) have a five-year survival rate of about 92%, but this drops to only about 36% when the cancer has progressed to an advanced stage. We therefore believe that these dopamine receptor probes show great promise for the development of molecular diagnostic tools for the early detection of cancer."

Dr Ma added that because the probes could successfully track the internalisation process of dopamine receptors in cells, they also represent powerful tools for studying the role of dopamine receptors in the pathogenesis of cancer.

Media enquiries:
Tina Ng of the Communication and Public Relations Office (+852 3411 5262) or Dr Edmond Ma of the Department of Chemistry (+852 3411 7075)

# # #


Submitted by ACN Newswire, ACN Newswire on Wednesday, 16 May 2018 at 12:31 PM
Category: Health Care & Medical
 
Related News

Benefits of Ostarine MK2866
Monday, 16 Jul 2018

Find Best Mobility Scooters For Elders to Travel Without Depending on Others
Saturday, 14 Jul 2018

Small Molecule Targeted Cancer Therapy Market to Record an Exponential CAGR by 2019
Friday, 13 Jul 2018

Infant Incubator Market -Value Chain and Stakeholder Analysis
Friday, 13 Jul 2018

Wound Care Active Therapies Market -Size and Key Trends in Terms of Volume and Value 2017-2025
Friday, 13 Jul 2018

Related Events

Success With Failure: Strategies for the Evaluation and Treatment of Heart
Sunday, 15 Jul 2018

World Congress on Prevention of Diabetes And its Complications Edinburgh 2018
Sunday, 15 Jul 2018

Mayo Clinic Diagnostic Imaging Update and Self-Assessment
Monday, 16 Jul 2018

2nd Real-World Evidence Forum
Monday, 16 Jul 2018

Tumor Models | Boston 2018
Monday, 16 Jul 2018

Latest News

Dragons Awaken Adds Soccer Mania To Its Gameplay To Celebrate Football World Cup
Monday, 16 Jul 2018

SuperBtc Ltd Introduces New Innovative Investment Strategies In Bitcoin Trading
Monday, 16 Jul 2018

Benefits of Ostarine MK2866
Monday, 16 Jul 2018

What Would be the Standard Video Game Tester Requirements?
Monday, 16 Jul 2018

TCXhub Crypto Exchange Platform To Launch
Sunday, 15 Jul 2018

 
Want to get your press releases, event listings, and job ads on Scoopasia? Register now for a FREE account or login if you already have one!
Scoopasia v1.0b. Copyright © 2018
Today is Monday, 16 July 2018

About Scoopasia | FAQ | Privacy Policy | Contact Us

Press Releases
Event Listings
Job Listings
Arts & Entertainment
Architecture & Construction
Automotive & Travel
Business
Consumer Technology
Economy
Education
Enterprise Technology
Food & Fashion
Government & Policy
Health Care & Medical
Legal/Law
News & Media
Religion
Science & Research
Sports & Fitness
Login / Register
Get Scoopasia through RSS Feeds & Email Notifications!


Journalist's Toolbox
Hello journalist, welcome to Scoopasia--a powerful online resource for media information in Asia. Scoopasia has press releases and media events for every beat and industry. All content on Scoopasia is 100% FREE. You don't even need to login!

  • Scoop Line
    (Instant Information Request)
    The easiest way to ask questions and request information from the PR community.


  • Advanced Search
    Drill down, dig deep, for media information the way you want it.

  • Journalist's Resources
    Resources and tools you can't do without.

  • PR Tools
    Scoopasia Blog Search
    Search the largest handpicked collection of Asia's most prominent and influential blogs.


    Resources
  • PR Bookmarks
  • Web 2.0 Bookmarks
  • Media Bookmarks

    More Coming Soon...

  • Upcoming Events
  • Investment Properties for Sale
  • Success With Failure: Strategies for the Evaluation and Treatment of Heart
  • Mountain Adventure Summer Camp Verbier Switzerland
  • Best Summer Camp Switzerland
  • World Congress on Prevention of Diabetes And its Complications Edinburgh 2018

  • Latest Jobs
    Sorry, there are currently no entries posted here.